Longevity
Biomarkers, healthy aging, preventative health, and lifespan research.
88 articles in Longevity · page 7 of 8
AMPK, Exercise, and Longevity
The energy-sensing enzyme behind both exercise and metformin — and why the human longevity evidence for it is still thin.
Read →mTOR and Aging: The Central Pathway
The nutrient-sensing pathway behind rapamycin, fasting, and the protein debate — and what the human evidence actually shows.
Read →Fasting and Longevity: What the Human Data Shows
Separating the compelling animal fasting results from the more modest human evidence — what has actually been measured in people, and how.
Read →Autophagy, Explained: Separating Science From Hype
Cellular self-cleaning is real, Nobel-winning biology — and badly oversimplified in wellness marketing. What the science holds.
Read →Caloric Restriction: Lessons From the CALERIE Trial
CALERIE is the closest thing to a controlled human caloric-restriction study. What it found on metabolism and biomarkers, and its limits.
Read →Time-Restricted Eating: Evidence and Limits
What randomized trials show about eating windows — and why matching calories erases most of the advantage attributed to them.
Read →Epigenetic Clocks: How Biological Age Is Measured
What epigenetic clocks actually measure, what they predict, and where they fall short as a personal read on how fast you are aging.
Read →The Hallmarks of Aging, Explained
The framework that organizes modern aging science, in plain language: nine hallmarks in 2013, twelve by 2023, and what changed.
Read →Muscle Mass and Lifespan: The Protein Connection
Grip strength predicts mortality and older adults need more protein per meal. What the evidence shows about the muscle-lifespan link.
Read →Fisetin and Senescence: Reading the Early Data
Fisetin is a plant flavonoid studied as a senolytic, riding mostly on preclinical promise. What the early human data does and does not show.
Read →Grip Strength as a Longevity Marker
In a 140,000-person study, lower grip strength predicted death better than systolic blood pressure. Why the marker works so well.
Read →NMN vs NR: Comparing the NAD+ Precursors
Two popular ways to raise NAD+. Both move the biomarker, and neither has a head-to-head human trial to crown a winner yet.
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