Longevity
Biomarkers, healthy aging, preventative health, and lifespan research.
88 articles in Longevity · page 5 of 8
The Epigenetics of Lifestyle
How daily behaviors leave marks on gene expression, what is actually reversible, and where the epigenetics story gets oversold in marketing.
Read →Klotho: The Longevity Protein, Explained
A protein tied to aging and cognition, with striking mouse data and no validated way to raise it in people. Where it stands.
Read →Hormesis: Why a Little Stress Helps
A real dose-response principle with strong lab data — and uneven human outcome evidence. Where it holds up, and where it is extrapolation.
Read →Stem Cells and Aging: Hype vs Reality
Only blood-forming stem cell therapies are FDA approved; anti-aging clinic products are not. What the science supports, and what it doesn't.
Read →Plasma Dilution and Young Blood: A Skeptic's Look
Mouse work suggests diluting old plasma, not adding young blood, drives rejuvenation. Human proof is still entirely absent.
Read →Taurine and Aging: Reading the Findings
Taurine raised mouse lifespan about 10-12% in 2023, but the human evidence stays observational. How to read the findings without overclaiming.
Read →Urolithin A and Mitophagy
Urolithin A has real randomized human trials — and most of them missed their primary endpoints. What the data actually shows.
Read →Spermidine and Autophagy: Reviewing the Evidence
A 12-month RCT found no significant memory benefit from spermidine, despite promising autophagy biology. How to read that gap honestly.
Read →GLP-1s and Longevity: An Emerging Intersection
GLP-1 drugs cut cardiovascular events in trials — but no human data shows they slow aging itself. Where the intersection actually is.
Read →The Blue Zones: What Holds Up and What Doesn't
Sorting durable lessons from storytelling in the famous longevity hotspots — including a serious challenge to the underlying data.
Read →Inflammation Markers: hs-CRP and Aging
hs-CRP is a widely available marker of the inflammation that tracks with aging and disease. How to read it, and what moves the number.
Read →ApoB and Cardiovascular Longevity
Why this one lipid marker may track atherosclerosis more directly than the standard cholesterol panel you are used to seeing.
Read →