GLP-1 & Metabolic
Metabolic health, appetite regulation, and modern weight management.
116 articles in GLP-1 & Metabolic · page 6 of 10
Semaglutide and Cardiovascular Risk: What SELECT Actually Showed
The SELECT trial found a 20% reduction in major cardiac events in people with heart disease and excess weight — and it changed the drug's FDA label.
Read →The Side-Effect Curve: Why Most Quit in Month One
What the pivotal trials and a real-world cohort show about GLP-1 side-effect timing and when people quit — the early-quit story is half right.
Read →GLP-1s for Maintenance vs Active Loss
In the STEP 1 extension, people regained two-thirds of lost weight a year after stopping semaglutide. Maintenance needs the drug.
Read →What 'Food Noise' Tells Us About Obesity Biology
A patient-coined phrase is reframing appetite as biology. What the brain-imaging evidence does and does not yet support.
Read →GLP-1s and Mental Health: Untangling the Signals
Regulators found no causal link to suicidal thoughts, but the data still cannot promise mood neutrality for every individual.
Read →Can Training Offset GLP-1 Muscle Loss?
Resistance training is the obvious lever against lean-mass loss. What the evidence says it can protect on a GLP-1, and what it cannot.
Read →Cardiometabolic Risk: Where GLP-1s Fit
In SELECT (NEJM 2023), semaglutide cut major cardiovascular events 20% in high-risk adults. Where the class fits overall.
Read →Tolerance to GLP-1s: Does It Happen?
Does the body adapt and the weight effect fade? What multi-year semaglutide and tirzepatide trials actually show about it.
Read →GLP-1s and Insurance Coverage in 2026
Medicare's weight-loss exclusion, the temporary GLP-1 Bridge, 13 Medicaid states, and employer variation — the documented coverage picture, with dates.
Read →The History of Incretin Research, Briefly
From secretin in 1902 to tirzepatide in 2022: the verified dates and names behind the incretin story, and the long gaps between them.
Read →GLP-1s and Appetite Hormones: Leptin and Ghrelin
How GLP-1 drugs interact with the body's other hunger signals — leptin and ghrelin — and why appetite regulation is more than one hormone.
Read →How GLP-1s Slow Gastric Emptying
The mechanism behind both the fullness and the nausea on a GLP-1 — how much gastric emptying slows, and why the effect fades over time.
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