GLP-1 & Metabolic
Metabolic health, appetite regulation, and modern weight management.
116 articles in GLP-1 & Metabolic · page 3 of 10
How Much GLP-1 Weight Loss Is Fat vs Muscle?
What the DEXA substudies of semaglutide and tirzepatide show about GLP-1 fat vs muscle loss — how much of the weight is lean mass, and how to protect it.
Read →GLP-1 Weight Loss by Starting Weight: Why % Beats Pounds
Why GLP-1 weight loss is reported in percent, not pounds — how the same percentage becomes very different pounds, and what the trials show.
Read →How to Measure Whether You're Actually Losing Muscle
DEXA, BIA, the scale, and a tape measure each say something different about muscle loss on a GLP-1. What each can and cannot actually reveal.
Read →Is Your GLP-1 Weight Loss Normal? Benchmarking the Curve
Average monthly weight loss on Wegovy and Zepbound, straight from the trials — a benchmark for your own progress, and why the range is wide.
Read →When Does GLP-1 Weight Loss Start? The First Month
What the trials show about GLP-1 weight-loss onset in the first month, why the starting dose is deliberately slow, and what is normal early.
Read →Average Weight Loss on Zepbound: The SURMOUNT Numbers
What SURMOUNT-1 found for tirzepatide by dose: average percent loss at 5, 10, and 15 mg — and why an average is not a promise for anyone.
Read →The Three Levers of Muscle Retention: How the Planner Weighs Them
Rate of loss, protein, and resistance training are the three levers of muscle retention. How the Lean-Mass Preservation Planner weighs each one, and why.
Read →Muscle Loss in Older Adults on GLP-1s
Why the same percentage of lean-mass loss matters more with age: sarcopenia risk, anabolic resistance, and how to protect muscle on a GLP-1.
Read →How Long Semaglutide and Tirzepatide Stay in Your System After the Last Dose
Semaglutide's half-life is ~1 week and tirzepatide's ~5 days. How to reason about washout: roughly 5 weeks and 4–5 weeks to be practically cleared.
Read →Why GLP-1 Titration Schedules Work With the Kinetics
GLP-1 dose escalations hold each step for about four weeks for a reason: it lets blood levels plateau at one dose before the next step raises the ceiling.
Read →Turning a Protein Target Into Daily Grams
How to turn a g/kg protein target into a real daily gram figure for muscle retention — and why GLP-1 appetite suppression makes it harder.
Read →How Fast Should You Lose Weight on a GLP-1 to Protect Muscle?
Rate of loss is a lever for muscle retention. Why aggressive deficits cost lean tissue, and the percent-per-week pace that protects it.
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